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These observations clearly support the anticancer effects of polyphenols by changes in the cancer cells epigenome [180]

High expression of Glo1 may contribute to MDR by shielding the spliceosome from MG modification and decreasing survival in chemotherapy

Although there are studies reporting nephrotoxicity and impaired renal function associated with repeated administrations of GBCAs, the frequency of exposure used in most research studies poorly mimics the use of these agents in clinical practice, and some research studies were carried out in models of advanced stage of renal disease

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