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The main toxicity provoked is acute liver damage, which is mechanistically provoked by the aberrant adduction of the toxic metabolite N-acetyl p-benzoquinone imine (NAPQI) to cysteinyl residues of key liver proteins [105]
[DOI] [PubMed] [Google Scholar] 221.Liu B., Zhu C., Dai L., Zhang L., Xu H., Ren K., Zhang H., Wang G., Tian W., Zhao D
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doi: 10.1016/j.etap.2022.104013 17 JanardhanamM.SivakumarP.SrinivasanG.SivakumarR.MarcusP
Data analysis Raw files were searched through Proteome Discoverer v.2.3 (Thermo Scientific) and spectra were queried against the human proteome (database downloaded from uniprot.org on 02/12/2019, containing 73662 sequences) using Sequest HT with a 1 % false discovery rate (FDR) applied
Fei et al., 2022a) and decreasing GATA-3 (Fei et al., 2020), and through NF-B signaling pathways, STAT1 and STAT3 (95)
