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The European Food Safety Authority (EFSA) sets the adequate intake (AI) for adolescents and adults at 4 g vitamin B12 per day

Safety and Regulatory Guidelines When considering regenerative therapies, ensure treatments are either FDA-approved or part of a registered clinical trial listed on ClinicalTrials.gov

A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

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Underlying health conditions: Liver, kidney, or immune system issues require professional guidance

Supplementation might benefit those with deficiency-related symptoms