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Samples were fixed in 10% buffered formalin overnight at 4C, dehydrated with increasing concentrations of ethanol, embedded in paraffin, cut into 5 m sections, and stained with hematoxylin and eosin (HE) or Massons Trichrome Stain Kit (Sigma-Aldrich)

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The study characterized the degradation kinetics of AOD9604 in biological matrices and identified the specific cleavage products generated by endogenous proteases

By providing a 3-month supply of medication and all necessary supplies up front, patients stay fully equipped, avoid treatment gaps, and remain psychologically engaged in their journey leading to better outcomes and long-term success