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Despite these questions, the use of MRTs in humans, both pronuclear transfer and maternal spindle transfer, was approved in the United Kingdom on 29 October 2015, by the Human Fertilisation and Embryology Act , however, the first child was not born until 8 years later ( Further, in light of (pending) approvals to use these techniques clinically, it is imperative to note that mismatches between mitochondrial and nuclear genomes may occur during this process (Farnezi et al., 2020)

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