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Supported by the substantial weight-loss efficacy of the GLP-1MK-801 conjugate and the potentiated hypothalamic changes in transcripts and proteins related to NMDA receptor-linked neuroplasticity, the alteration in MK-801 biodistribution governed by GLP-1-mediated targeting may effectively bypass the delivery of MK-801 to vagal afferent target neurons in the nucleus of the solitary tract

[DOI] [PubMed] [Google Scholar] 182.Polonikov A

doi: 10.1038/s41467-021-22336-4

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Indeed, short-term glutaminolysis induces mTORC1 lysosomal translocation and activation via the Rag GTPase, then inhibiting autophagy and promoting cell growth [88]