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A study conducted in 2006 on patients with Hashimoto thyroiditis demonstrated a significant positive correlation between elevated serum IL-6 levels (a pro-inflammatory cytokine) and the required L-T 4 dose

The most likely candidates among them may be -aminobutyraldehyde dehydrogenase PatD that is active with unmethylated TMABA (-aminobutyraldehyde) or with betaine aldehyde (Samsonova et al., 2005) and PuuC, a non-specific aldehyde dehydrogenase that oxidizes all aldehydes in putrescine catabolism including -aminobutyraldehyde (Schneider and Reitzer, 2012)

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To determine whether variants in novel genes contribute to this disorder, we evaluated TMA metabolism by choline challenge, conducted a sensory evaluation and sequenced the exome of ten subjects with complaint of TMA-related body odor

Curr Treat Options Oncol

The first one is the less optimal methodological quality of the included studies, so bias cannot be excluded