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RBCs RBCs are the cell type most sensitive to oxPPP loss

405 Most patients with severe thalassemia experience complications of iron overload due to blood transfusions, which promote oxidative damage to various organs, leading to endocrine and ultimately organ dysfunction

Although macrophages have a remarkable ability to tolerate iron overload [117], the antioxidant capacity of macrophages is insufficient to cope with iron overload in this setting

6 Proposed Brnsted base mechanism of GST catalysed reactions

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On the other hand, pheomelanin synthesis might consume cellular antioxidant stores and make the cell more vulnerable to other endogenous ROS (Fig