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Conditions affecting any stage of this absorption pathwayincluding pernicious anaemia (an autoimmune condition destroying intrinsic factor-producing cells), Crohn's disease, coeliac disease, or surgical removal of stomach or ileal tissuecan significantly impair B12 absorption despite its water-soluble properties

Afonine PV, Grosse-Kunstleve RW, Echols N, Headd JJ, Moriarty NW, Mustyakimov M, et al

The NewcastleOttawa Scale consists of three main assessment categories: Selection (adequate definition of cases, representativeness of cases, selection of controls, definition of controls), Comparability (control for important factor or additional factor), and Exposure (ascertainment of exposure, same method of ascertainment for cases and rate controls, Non-Response rate)

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When laser light irradiates accumulated PS reagents (e.g., bilirubin), photoactivation generates toxic ROS and induces cell death to provide local antitumor therapy