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Notably, Tan II A also modulates the TGF-/Smad pathway, not as a uniform fibrotic regulator, but in a context-dependent manner that promotes epithelial re-differentiation, reduces stromal hyperactivation, and suppresses expression of invasion-associated genes such as SNAIL and TWIST and apoptosis-resistance genes such as Bcl-xL , thereby improving tissue architecture and restoring apoptotic responsiveness in EMs models (Zhang et al., 2023)

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Those with pre-existing cardiac conditions or on medications affecting potassium levels may require closer monitoring

[DOI] [PubMed] [Google Scholar] 43.Winterbourn C.C., Metodiewa D

J Neurochem 123(Suppl 2):8697 Khan M et al (2011) S -nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats