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The largest Phase 2b trial (502 participants, 24 weeks) did not show statistically significant weight loss versus placebo

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Summary: B12 injections begin working at a cellular level immediately, though noticeable symptom improvement typically occurs within 4872 hours to several weeks depending on deficiency severity

Pernicious Anemia: This is an autoimmune disorder where the body mistakenly attacks a protein in the stomach called "intrinsic factor." Without this protein, you simply cannot absorb B12 from food, making injections a lifelong necessity