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Most studies to date have analyzed the modifying effects of the RhD phenotype rather than the RhD genotype

10) Hormonal and Endocrine Effects Because metabolic pathways interact closely with endocrine signaling, potential secondary hormonal effects may include: Thyroid function fluctuations Cortisol changes Insulin sensitivity alterations While some research suggests improved metabolic efficiency, endocrine dysregulation remains a theoretical concern without long-term human studies

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