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To determine the protective effect of Epitalon on the integrity of aging oocytes, ovulated oocytes were cultured with increased dose of Epitalon (0.05, 0.1, 0.25, 0.5, 1, 2mM) for 24 h

10.1038/nature18848 Nature 63 HuangL.GaoR.YuN.ZhuY.DingY.QinH
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furthermore, the abundance of Erysipelotrichales (especially Faecalibaculum and Dubosiella) , which might produce and secrete Hcy, inducing host HHcy, was higher in the HM fed mice, while Rikenellaceae (especially Alistipes) were lower

Loree JM, Lam M, Morris J, Overman MJ, Raghav KPS, Eng C, Dasari A, Kee BK, Fogelman DR, Wolff RA, Jiang Z, Davis JS, Shaw KR, Broaddus R, Routbort M, Luthra R, Maru DM, Menter D, Meric-Bernstam F, Kopetz S