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In vivo studies confirmed that Ghrelin significantly activated the BMP6/SMAD1 signaling pathway in the brain tissue of AD mice, thereby inhibiting microglial ferroptosis, promoting microglial polarization toward the M2 phenotype, and ameliorating learning and memory deficits in AD mice (Guo et al., 2025b)
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Another 2022 double-blind study (n=48) combined GHK-Cu with hyaluronic acid, showing 25% fine line reduction and 18% hydration improvement at 8 weeks (An et al., 2022)
10.1111/acel.13261 18 CalcabriniC.MaffeiF.TurriniE.FimognariC
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