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All human genes associated with these categories were obtained by propagating gene membership in the GO hierarchical tree using the GO.db (v.3.14), AnnotationDbi (v.1.56.2) and org.Hs.eg.db (v.3.14.0) packages in R (date of access: 7 April 2022)

3.1.2 Indirect communication between CORT and immunity Indirect communication with the immune system is accomplished through the transmission of arachidonic acid-like signals (168)

Miyagawa et al., when comparing the intervention group (L-carnitine) and the placebo group observed a marked reduction in the total siesta time during the day in the first group (L-carnitine: 4934 min/day sleeping

10.1002/jcp.27264 180 ZhouJ

Indeed, BH4 has emerged as a critical regulator of redox homeostasis in macrophages, where loss of GCH1 promotes the accumulation of iNOS-dependent and -independent ROS and impairs NRF2 activation [216]

Aschner M, Aschner JL (1990) Mercury neurotoxicity: mechanisms of blood-brain barrier transport