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Strategies that may reduce side effects include: Eating smaller meals Avoiding high-fat or heavy foods Maintaining hydration Following the prescribed titration schedule Serious but Rare Risks Serious side effects are uncommon but may include: Pancreatitis Gallbladder disease Severe dehydration Kidney complications (often related to dehydration) There is also a boxed warning regarding thyroid C-cell tumors observed in animal studies

Anna Louie Sussman is a New York-based journalist with extensive experience reporting on gender, economics, health, and reproduction

Weight loss and engagement: January 2026 analysis of 14,203 Noom GLP-1 Rx Program members who started a GLP-1 Rx plan between December 2024 and February 2025 and logged weight during a measurement week (4, 8, 16, 40 weeks)

Stauber AJ, Credille KM, Truex LL, Ehlhardt WJ, Young JK

According to the FDA-approved prescribing information, gastroesophageal reflux disease is listed among the common adverse reactions for Zepbound (tirzepatide for weight management), while dyspepsia (indigestion) is listed for Mounjaro (tirzepatide for type 2 diabetes)

Foods high in protein, fiber, and healthy fats can trigger the release of GLP-1, an important hormone that helps regulate blood sugar levels and promotes a feeling of fullness