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The mitochondrial DOX-Fe 2+ complex induces triggers lipid peroxidation, resulting in mitochondria-dependent ferroptosis and decreased cardiac function in mice, which is reflected in significantly reduced left ventricular ejection fraction and myocardial fibrosis

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10.1016/j.tins.2020.05.004 2

doi: 10.1016/j.lwt.2017.10.061