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Jun 6 2022;58(6)doi:10.3390/medicina58060770

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[Crossref] Andrs E, Kurtz JE, Perrin AE, Maloisel F, Demangeat C, et al

Interestingly, body weight reduction was not observed in female KO mice because estrogen inhibits the expression of ANGPTL8, a finding further proved by ovariectomy in female mice

It is this reproductive aging process that determines when you enter into perimenopause, menopause and finally, settle into post-menopausal life