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10.1038/nrm.2016.140 241 Saint-GermainE.MignaccaL.VernierM.BobbalaD.IlangumaranS.FerbeyreG

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But the long-term safety is completely unproven , and there are plausible mechanisms by which things could go wrong (such as promoting tumor growth or causing unwanted tissue changes)

Preclinical studies show that PX-12 impedes hepatocellular carcinoma cell proliferation in vitro and curtails tumor dimensions in mouse models by instigating ROS-dependent apoptosis [226]
