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Nephropathy in Dietary Hyperoxaluria: A Potentially Preventable Acute or Chronic Kidney Disease

(2024) 7:e244525

The administration of live vaccines is contraindicated in patients on biologic agents and tofacitinib[71,72,86,95,102,112]

To further strengthen this conclusion, we performed isotope tracing analysis using [U- 13 C6]Leucine to assess BCKDH activity (Fig

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Abbreviations PDAC pancreatic ductal adenocarcinoma, OAT ornithine aminotransferase, ODC1 ornithine decarboxylase 1, DON 6-diazo-5-oxoL-norleucine, DRP-104 sirpiglenastat, MDH1 Malate dehydrogenase 1, BCAA branched-chain amino acid, BCAT2 BCAA transaminase 2, O-GlcNAcylation O-linked -N-acetylglucosamine, CRC colorectal cancer, SLC25A21 solute carrier family 25 member 21, SLC25A22 solute carrier family 25 member 22, YAP1 yes1 associated transcriptional regulator, AAT amino acid transporters (SLC7A5/LAT1, SLC38A2/SNAT2, and SLC1A5/ASCT2), mTOR mechanistic target of rapamycin, NSCLC non-small cell lung cancer, SLC7A1 solute carrier family 7 member 1, ASS1 arginine succinate synthase 1, ATF4 activating transcription factor 4, NRF2 nuclear factor erythroid 2-related factor 2, LUAD lung adenocarcinoma, STAT3 signal transducer and activator of transcription 3, SLC7A11 solute carrier family 7 member 11, KEAP1 Kelch Like ECH Associated Protein 1, LKB1 liver kinase B1 Najumudeen observed that KRAS rewires the amino acid metabolism in colorectal cancer (CRC) tumorigenesis through its dependency on SLC7A5, a glutamine antiporter