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Consistent with RDoC and NIMH initiatives, we assess symptoms dimensionally rather than relying solely on categorical diagnoses, providing greater sensitivity to subthreshold variation [66, 67], facilitating transdiagnostic comparisons, and improving power to detect brainbehavior associations

104,116 Notably, two distinct clones of MDCK, namely, MDCK1 (without expression of pore-forming claudins) and MDCK2 (endogenous expression of pore-forming claudins), can be used for experiments on pore pathway permeability

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Once a patients Vitamin B12 levels normalize, we transition to a maintenance therapy approach, ensuring that the recurrence of deficiency is prevented

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Vitamin B12 can be administered through intramuscular or subcutaneous injections