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doi: 10.1146/annurev.arplant.50.1.47 36
Conventional drug conjugation methods are either through less precise interchain disulfide Cys or random lysine residue in the antibody components, resulting in a huge product heterogeneity with limited control over the conjugation locations
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PubMed , Cleveland Clinic , Accessed 19 Jan
Early metabolic analyses have confirmed that severe COVID-19 patients exhibit profound deficiencies in circulating glutamine, which correlates directly with immune exhaustion and endothelial dysfunction
