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The findings highlight the complex hormonal regulation of adipose tissue in lipedema and point to new therapeutic possibilities, including targeting estrogen metabolism, inflammation, and fibrosis

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Cell lysates were resolved by liquid chromatography on a Vanquish UHPLC system on a silica column using a gradient from 50:50 acetonitrile:water with 0.1% formic acid to 1:99 acetonitrile: water with 0.1% formic acid at a flow rate of 300 l/min, or on a HILIC column using a 50:50 acetonitrile:water with 0.1% formic acid and 5mM ammonium formate 50:50 methanol:water with 0.1% etc

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We further showed enhanced resistance to Salmonella infection since we had this model in the lab at the time