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One of the earliest events associated with APAP intoxication and excessive NAPQI generation is depletion of GSH stores, both the cytosolic and mitochondrial pools (45)

Compared to the fortified flour, the boiled noodles contained 69% less 5-methyl-THF fortificant 457

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Intracellular production of OH from H 2 O 2 is driven by the Fenton reaction, shown in Reaction 3 (43, 44, 48): As the most reactive known ROS, OH reacts with nearly all intracellular building blocks and macromolecules (amino acids, nucleic acids, phospholipids, sugars, proteins, RNA, DNA, lipids, polysaccharides)

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