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The medium in the basolateral chamber was collected at different time points and fluorescence signals were recorded using a microplate reader (FLUOstar Omega, BMG Labtech, Ortenberg, Germany) at excitation/emission wavelengths of 480 nm/530 nm, respectively

It is postulated that this mechanism may make younger women more prone to developing a secondary breast cancer due to the increased levels of both IGF1 and estrogen during puberty, and the promoting effects of IGF1 41, 94

[30] [31] There is no evidence base for these combinations alongside an investigational agent

rhamnosus Distinguished by its tolerance to extreme GI pH gradients, this species is also industrially significant for driving organoleptic changes in cheese maturation ( 3.1.3 Lactobacillus fermentum Characterized by high auto-aggregation and adhesive capacity, strain JDFM216 exhibits strong anti-infective and antioxidant properties ( 3.1.4 Lactobacillus johnsonii Exemplified by the seminal strain LA-1, this species is noted for its resilience to bile and antibiotics ( 3.1.5 Lactococcus lactis A primary species in probiotic research, specific strains like ML-2018 demonstrated potent anti-inflammatory activity by downregulating LPS-induced cytokines ( 3.1.6 Lactobacillus reuteri This species offers a broad therapeutic spectrum, ranging from urogenital health and dental caries prevention to the management of infantile colic ( 3.2 Bifidobacterium species: therapeutic and functional profiles The genus Bifidobacterium comprises a diverse group of probiotic bacteria critical for maintaining GI homeostasis and developing functional therapeutic applications ( Table 2 )
