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Grx exhibit site-specific distribution with Grx1 being specifically located in cytosol while Grx2 localizes in mitochondria

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THP-1 cells were differentiated into macrophages by 100 nM of phorbol-12-myristate-13-acetate (Sigma-Aldrich), and differentiated into M1 by adding LPS (100 ng/mL, Sigma-Aldrich) and IFN- (20 ng/mL, R&D Systems) for 24 h, and M2 cells with M-CSF (20 ng/mL, Peprotech), IL-4 (40 ng/mL, R&D Systems), and IL-13 (40 ng/mL, R&D Systems) for 4 days

[DOI] [PubMed] [Google Scholar] 153.Plemel J.R., Juzwik C.A., Benson C.A., Monks M., Harris C., Ploughman M

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cagrilintide does it via the amylin receptor (AMY1R/AMY3R heterodimers) in the area postrema