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This is because impaired kidneys do not effectively metabolize or excrete homocysteine, resulting in the buildup of this amino acid in the bloodstream

Efficacy of adding pain neuroscience education to a multimodal treatment in fibromyalgia: a systematic review and meta-analysis

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10.1161/jaha.116.004237 [DOI] [PMC free article] [PubMed] [Google Scholar] Senthong V., Wang Z., Li X

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Activation of the vascular endothelial growth factor receptors affects angiogenesis by inducing cell proliferation, cell survival, and vascular permeability