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The System Xc/GPX4 pathway, with core genes GPX4 and SLC7A11 , is essential for cells to resist lipid peroxide-induced oxidative stress and ferroptosis 50

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Using a mouse macrophage cell line, the authors show that IFN-gamma and endotoxin increase both nitric oxide (NO) production and bactericidal activity

Depletion of glutathione eventually leads to excessive lipid peroxidation and cell death