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[10] The perceived benefits of these supplements were a stronger immune system, increased energy levels and muscle strength, and improved speech and language development

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Direct provision of TMAO into diet has been shown to increase the development of atherosclerosis in animal models, confirming its pro-atherogenic properties 47 and multiple clinical studies have confirmed that an elevated TMAO level is associated with increased risks for incident major adverse CV events 48

TMAO activates its intracellular potential receptors, protein kinase R-like endoplasmic reticulum kinase (PERK), which further activates NLRP3 and NF-B that mediate pro-inflammatory responses

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