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Pfizer axed a twice-daily version of the only obesity product in its pipeline earlier this month after patients taking the pill lost significant weight but had trouble tolerating the drug in a mid-stage study

But there was no report showing the factors that contribute to GLP-1 receptor expression in human artery

SELECT: Semaglutide Reduces Risk of MACE in Adults with Overweight or Obesity

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As with native GLP-1, semaglutide acts to stimulate insulin secretion and inhibit glucagon release depending on the blood glucose concentration, leading to improved blood glucose levels together with a reduced risk of hypoglycaemia [1, 2]