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Zegers-Hochschild F, et al

Right around the onset of adolescence, the vast majority of children experience a large decline in B12 that should remain constant throughout adulthood with proper nutrition and the absence of pregnancy (2)

Earlier studies suggested that PA was restricted to Northern Europeans, but subsequent studies indicate that PA affects virtually all ethnic groups.37 Pernicious anaemia was considered a classical cause of vitamin B 12 deficiency before food-cobalamin malabsorption was described, and accounted for 15% to 25% of vitamin B 12 deficiency in the elderly in studies.9 In a local study on 296 Chinese patients, definite PA was diagnosed in 61% of patients having megaloblastic anaemia with vitamin B 12 or folate deficiency.38 Pernicious anaemia is characterised by destruction of gastric mucosa, especially fundal mucosa, primarily by a cell-mediated mechanism.39 There is progressive destruction and eventual loss of intrinsic factor producing gastric parietal cells

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A receptor that binds AGE is present in the plasma membrane of numerous cell types including immune cells, vascular endothelial cells, and smooth muscle cells