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Our current PCT included 225 participants, 49.78% (112/225) of whom were overweight or obese

Therefore, an altered redox state of the ETC induced by inhibiting ETC electron carriers can increase superoxide production, contributing to an imbalance in the cellular redox state, which may cause oxidative stress [102,103]

however, the PAD4 inhibitor GSK484 partially attenuated both joint ferroptosis and these altered gut microbiotas (Zhu et al., 2025)

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