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The heart, brain, muscles, and testicles contain considerable concentrations of ALC but the levels are dramatically reduced as we age

Dysregulation of the hypothalamicpituitary-ovarian axis, driven by increased LH secretion, stimulates theca cell hyperplasia and enhances the expression of enzymes critical for androgen biosynthesis, thereby promoting excessive androgen production (10)

Expectation: Slow, modest improvements in endurance and substrate handling, when combined with regular training

Many studies have reported reduced L-carnitine (LC) levels in these patients

Our findings of increased serum palmitoyl-L-carnitine with aging are consistent with observations in heart failure and coronary artery disease [56], where elevated levels likely result from disrupted mitochondrial fatty acid oxidation and impaired -oxidation, leading to acylcarnitine accumulation [57]