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SARS-CoV-2 ACE2-mediated host cell invasion is enhanced by the presence of heparan sulfate proteoglycans (HSPGs) consisting of a core protein bearing glycosaminoglycan carbohydrate chains (Souza-Fernandes et al., 2006

the process involves multiple factors, including an inflammatory factor storm, cell death, the immune response and oxidative stress

Astragalus polysaccharides can also promote M1 polarization in TAMs, activate the TLR4-MyD88-dependent pathway through TLR4 and subsequently promote the expression of TRAF-6, NF-B, and AP-1

[DOI] [PubMed] [Google Scholar] Rietdijk, C

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However, the lack of treatment options for multi-drug resistant pathogens has led to the recovery of colistin as an antimicrobial agent, especially in its inhaled formulation (Lim et al., 2010)