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For example, in contracting skeletal muscle tissue, the sarcoplasmic reticulum Ca 2+ -ATPase (SERCA) facilitates calcium reuptake into the reticulum, preventing calcium overload in the sarcoplasmlikely in synergy with HSPA5 ( In addition to stabilizing cytosolic proteins, HSPA1A also protects proteins of membrane organelles from damage

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[DOI] [PubMed] [Google Scholar] 168.Hsiao YH, et al

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Protein Glutathionylation in Health and Disease

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10.1002/j.1536-4801.2004.tb00870.x 81

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Due to their high charge at physiological pH, however, permeation into cells can be a challenge

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