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B12 is a key player in the production of the mood-regulating chemical serotonin and when your body is lacking the vitamin, production can decrease

People taking certain common medications including metformin for blood sugar management and proton pump inhibitors for acid reflux also face increased deficiency risk

No safety data from the human trial was published

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions

Had the second 3 weeks later

The process takes under 5 minutes and follows the same technique used for all injectable peptides we prescribe in Doral