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Description
Several studies in murine models have demonstrated that DZN disrupts the activity of antioxidant enzymes, particularly glutathione peroxidase, which plays a critical role in renal metabolism [43]

LC-MS was performed essentially as previously described (Perez de Souza et al., 2019, 2021)

[DOI] [Google Scholar] 48.Tajik N, Frech M, Schulz O, Schlter F, Lucas S, Azizov V, Drholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Krnke G, Luo Y, berla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, Wirtz S, Caete JD, Ciccia F, Schett G, Zaiss MM

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This first-pass effect sensitivity has several important clinical consequences

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