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6 LDN is unlikely to precipitate withdrawal symptoms for patients on opioids at these low doses, but it is prudent to recommend that patients on continuous opioid therapy wean entirely off opioids before initiating LDN

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However, vitamin B12 can sometimes be difficult to absorb from food or pills, or we simply do not have enough vitamin B12 in our diet

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Likely, this may be a timely specific BPC 157 effect on ketamine-specific brain targets [59]
