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Patients taking immunosuppressants should use sun protective measures, undertake regular self-surveillance and report suspicious lesions to their clinician for urgent evaluation

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Morphologic features can be appreciated better in bleached sections

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Melanotan 1 (afamelanotide) is a linear peptide analogue with selective affinity for MC1R, while Melanotan 2 is a cyclic lactam analogue with broader affinity across multiple melanocortin receptor subtypes