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Description
When IGF-1 activates the tyrosine kinase domain of IGF-1R, it catalyzes the phosphorylation of IRS, which in turn triggers the PI3K/AKT signaling pathway

Arch Gen Psychiatry 57 : 6573

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Mol Cell 9: 387399 Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK (1997) PTEN, the tumor suppressor from human chromosome 10q23, is a dualspecificity phosphatase
