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As in the main experiments, no genotype differences were observed in the number of attacks received during the stress exposure (Additional file 1: Fig

4,52,53 A less common but important genetic factor affecting homocysteine metabolism pertains to the CBS gene, which encodes the enzyme cystathionine beta-synthase (CBS)

The elevated homocysteine creates further oxidative stress and neuroinflammation, which in turn damages the myelin sheath and worsens the cognitive dysfunction and neuropathy

Ming X, Stein TP, Barnes V, Rhodes N, Guo L

References Rashid, S, Meier, V, Patrick, H

Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein