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doi: 10.1093/humrep/deh725 56 Salas-HuetosABullMSalas-SalvadJ

Rac2 / PMNs isolated from mice have a defect in superoxide production, where production is restored upon reintroduction of wild-type Rac2 using retrovirus-mediated gene transfer (Filippi et al., 2004)

While this idea shows a more complex picture from the popular one where free radicals and oxidants are bad and antioxidants are good, it implies that GSH is an essential molecule not only in acting as an antioxidant but also in the absence of oxidative stress, as an endogenous signaling molecule

J Immunol 200:1254 Qaisiya M, Coda ZC, Bellarosa C, Tiribelli C (2014) Bilirubin mediated oxidative stress involves antioxidant response activation via nrf2 pathway

More moderate protective effects are observed with melatonin, vitamin D, and UA

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