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IGF-1 LR3 also contributes to the anti-aging effect and, therefore, could be used in the cosmetic industry and aesthetic medicine

Coto-Montes A, Tomas-Zapico C, Rodriguez-Colunga MJ, Tolivia-Cadrecha D, Martinez-Fraga J, Hardeland R, Tolivia D (2001) Effects of the circadian mutation tau on the Harderian glands of Syrian hamsters

Rosarugosides A and D from Rosa rugosa flower buds: their potential anti-skin-aging effects in TNF--Induced human dermal fibroblasts

The most studied candidates appear below with short context on how they work and how clinicians or researchers might combine them into protocols

doi: 10.1183/13993003.00148-2015 44 KawamatawongT

The blend of other ingredients present in the soap helps provide a smooth application and does not strip the skin of its natural moisture