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It has been demonstrated in melanoma cell lines that the direct transcriptional target of TGF-1-the Kruppel-like transcription factor GLI2 not only suppresses MITF through PKA/cAMP signaling 52 but also directly downregulates tyrosinase-related protein 2 (TRP2) by competitive inhibition of CREB 53
47 Within these complexes, where TNFR1 and RIP are ubiquitinated for NF-B signaling
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Ou X, Lee MR, Huang X, Messina-Graham S, Broxmeyer HE
Dvoriantchikova et al., 2023)
Combining them, they form even greater protection against oxidative damage
