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What also supports this therapeutic idea is that balanced 2 -AR agonists run the risk of therapeutic tolerance or loss of response with prolonged treatment, as data suggests that desensitization and downregulation of 2 -Ars occurs downstream of -Arr binding (Gagnon et al., 1998)

doi: 10.1186/s13287-019-1544-y [DOI] [PMC free article] [PubMed] [Google Scholar] 21

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[DOI] [PubMed] [Google Scholar] 483.Krishnaveni M., Mirunalini S

[DOI] [PubMed] [Google Scholar] 35.Li Y, Li W, Hoffman AR, Cui J, Hu J-F

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