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coli O111:B4 can disrupt BBB permeability by affecting the activity of P-gp, causing various neurotoxins and pathogenic microorganisms to fail to drain out of the brain (Veszelka et al., 2007

(Daejeon, South Korea) or Agilent Technologies

Users report noticeable fat reduction and improved body composition within 24 weeks of consistent use

Clin Biochem 32: 595603

Funding This study was supported by grants from the National Key Research and Development Program of China (2022YFC2503802), the Innovative Construction Foundation of Hunan Province (grant number: 2021SK4001), the National Natural Science Foundation of Hunan province,China (2023JJ30924), the National Natural Science Foundation of Changsha city, China(kq2208385), Scientific research project of Health Commission of Hunan Province (B202303076019) Ethics declarations Ethics approval and consent to participate Ethics approval and consent to participate is not applicable in this study

5B, C), while it partially reduced the accumulation of ROS (Fig