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ALA also lowered oxidative stress, promoted glutathione-related endogenous enzymes, and prevented mitochondrial apoptosis in cadmium-induced kidney injury [110,111,112]

As such, early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage

Likewise, most vascular studies use surgical ovariectomy rather than chemotoxic models

Burzangi, A

This coenzyme is essential for various biological functions

Studies have shown that high doses of antioxidants such as vitamin C, vitamin E or N-acetylcysteine can suppress adaptive cellular responses, impair exercise-induced mitochondrial biogenesis and even promote tumour growth in certain models by interfering with ROS-dependent signalling processes, apoptosis processes or immune activation [161,162]
