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doi: 10.1016/S0022-2275(20)42621-5 390 WelikovitchL

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Another major challenge lies in achieving effective CNS concentrations of TNF inhibitors, as many current compounds have limited permeability across the bloodbrain barrier

For instance, in one review, researchers looked at 22 studies and concluded that creatine supplementation led to an average strength increase eight percent greater when compared to placebo