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Gene Ontology (GO) analysis revealed that these iron metabolism genes primarily participate in autophagy-related biological processes (e.g., ATP6V1G2, ATP6V1H, and ATP6V1D)

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Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and chemosensitivity

The inherent complexity, inter-individual variability, and dynamic nature of this axis necessitate further research to elucidate precise molecular mechanisms, validate therapeutic targets, and develop robust, clinically applicable biomarkers