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Therefore, under prolonged physical stress, starvation, low metabolic rate, and low body temperature, torpor and hibernation have been shown to offer a robust state of tolerance and tissue preservation, as well as radiation resistance

Am J Physiol Lung Cell Mol Physiol 307:L597-604

Oxidative stress can cause these complications by activating the hexosamine pathway, the advanced glycation end products (AGEs) pathway and the diacylglycerol (DAG)-protein kinase C (PKC) pathway ( Hyperglycemia decreases G6PD activity through the activation of protein kinase A (PKA) and increase of intracellular oxidative stress, leading to chronic kidney injury, and diabetic kidney disease (DKD) (4345)

Many factors, such as age, menopausal status, hormonal therapy, lactation, family history, and high-penetrance germline mutations (e.g., BRCA1/2), all shape individual risk 10

Growth hormone plays a central role in maintaining lean tissue, supporting protein synthesis, and facilitating tissue repairfunctions that are particularly relevant to male performance, aging, and training adaptation

Among these modified proteins, we found DLD with a modification at Cys 477 , together with multiple proteins (31 out of 149, ~20%) belonging to components of the known interactome of DLD (Fig